TEER

MITRACLIP™ Transcatheter Edge-to-Edge Repair

MitraClip™ is the first minimally invasive TEER* therapy that delivers a life-changing treatment option for select patients with primary or secondary mitral regurgitation who would otherwise go untreated.1,2 MitraClip is the standard of care in TMVr built on the only proven mitral valve therapy with over 20 years of experience, an extensive body of clinical evidence, and more than 200K patients treated worldwide.3

*TEER is also referred to TMVr (Transcatheter Mitral Valve Repair)

Built to Repair. Proven to Restore.

MitraClip delivers uncompromising performance in TEER and sets the standard in clinical outcomes. With each generation of MitraClip, Abbott remains at the forefront of therapeutic expertise, partnering with heart teams to help select patients with MR reclaim their lives.

A better quality of life is possible for your patients with MR


MitraClip™ transcatheter edge-to-edge repair (TEER) is a minimally invasive treatment option for select patients with:

  • Significant Primary MR and prohibitive surgical risk
  • Significant secondary MR with remaining symptoms despite maximally tolerated GDMT

The Catalyst for a Significant Evolution in MR Guideline

MitraClip is the first TEER (TMVr) therapy recommended by AHA/ACC/HFSA and ESC/EACTS guidelines and ASPC recommendations for select primary and secondary* MR patients. The guidelines support aggressive monitoring and early action, with the goal of preventing complications due to LV volume overload.10-12


*Severely symptomatic SMR patients despite optimal GDMT.
 


Severe MR is vastly undertreated

  • Surgical intervention not offered or denied


    49% of patients with symptomatic severe MR were not operated due to age, co-morbidities, or impaired LV.5 If left untreated, MR initiates a cascade of events leading to death, with 1-year mortality up to 57%6

IDENTIFYING PATIENTS FOR MITRACLIP THERAPY


MitraClip Transesophageal Echo (TEE) Screening Guide
 

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MitraClip Procedural Positioning and Imaging Guide
 

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MitraClip Transthoracic Echo (TTE)
Screening Guide

 

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Tailored. Optimized. Proven.
MitraClip™ G4

MitraClip TEER system’s dedicated design for the mitral anatomy optimizes navigation for consistent clinical results. Its proven performance and tailored treatment options allow it to treat the broadest range of mitral anatomies.

  • Broad Range of Sizes for Tailored Treatment7,8,13

    MitraClip G4 offers 4 Clip sizes to help tailor repair based on patient mitral valve anatomy.

    • G4 NT is the original MitraClip NT/NTR Clip size
    • G4 XT is the equivalent of XTR, with Clip arms that are 3 mm longer than G4 NT and allow for easier grasping due to better reach**
       

    The G4 NTW and XTW clips have a 50% wider grasping area than the NT and XT clips respectively. They are designed to further reduce regurgitant volume reduce MR with the implantation of a single clip.**

  • Treat more patients with more options7-10,13

    MitraClip successfully treats a broad range of valve anatomies in real world use7-10,13

    Significant and durable MR reduction achieved in patients with complex anatomies7

    90.3% of complex subjects achieved MR <1+ at 1 year.7


    THIS WAS THE BEST MITRACLIP CASE WE HAVE EVER DONE...GEN 4 IS A GAME-CHANGER.

    – Experienced Interventional Cardiologist commenting on MitraClip G4*
     

    *The testimonial does not provide any indication, guide, warranty or guarantee as to the response patients may have to the treatment or effectiveness of the product or therapy in discussion. Opinions about the treatment discussed can and do vary and are specific to the individual’s experience and might not be representative of others.

    Ability to choose clip size based on each MV Anatomy8,9

    CLIP SELECTION CONSIDERATIONS

    FAVORS
    G4 NTW
    FAVORS
    G4 NT
    FAVORS
    G4 XTW
    FAVORS
    G4 XT
    Leaflet Length < 9mm++  
    Leaflet Length ≥ 9mm  ++
    Broad Jet+ + 
    Smaller Valve +  
    Larger Valve+ ++

    MitraClip G4 clip selection recommendations were based on the initial clinical experience of an expert panel of physicians.8,9

    The EXPAND G4 real world study results further demonstrated clip selection preference and associated outcomes:8

    FOR PATIENTS WITH PMR

    XTW was used most often and achieved favorable MR reduction, particularly in patients with longer leaflets, large prolapse or wider jets, calcified leaflets or annulus and Barlow’s or bileaflet prolapse

    FOR PATIENTS WITH SMR

    NTW and XTW were used evenly across anatomies and achieved favorable MR reduction

    FOR ALL MR ETIOLOGIES

    NT and XT were used more frequently in multiple-clip cases and improved MR reduction

  • More options to confirm and optimize leaflet grasping with Controlled Gripper Actuation (CGA)1,**

    Controlled Gripper Actuation (CGA) provides the option to grasp leaflets simultaneously or independently, enabling the ability to confirm and optimize leaflet grasp.

    NEW GRIPPER
    LEVERS

    SIMULTANEOUS
    GRASPING

    INDEPENDENT
    GRASPING

  • Predictable procedure experience**

    The innovative Clip Delivery System is a highly maneuverable delivery catheter that is used to implant the MitraClip via a Steerable Guide Catheter.

    Precision and control from delivery system specifically designed for the mitral valve**
     

  • Increased procedural efficiency1,7

    GREATER PROPORTION
    OF PATIENTS TREATED
    WITH 1 CLIP7

    ONLY 1 CLIP IN
    65% OF CASES7

     

    SHORTEST
    DEVICE TIME TO DATE IN TEER7

     

    35 MIN. MEDIAN
    DEVICE TIME7



    “IN OUR INSTITUTE, WE HAVE NOW REDUCED DEVICE TIME TO ~20 MIN.”

    Experienced Echocardiographer commenting on MitraClip G4*
     

    *The testimonial does not provide any indication, guide, warranty or guarantee as to the response patients may have to the treatment or effectiveness of the product or therapy in discussion. Opinions about the treatment discussed can and do vary and are specific to the individual’s experience and might not be representative of others.

    Simplified procedural steps1

    • 40% reduction in system preparation steps
    • Simplified system deployment with minimal number of steps
       

CLINICAL DATA


See the latest clinical data for MitraClip
 

see clinical data

MAT-2010221 v5.0 | Item approved for OUS use only.

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