TMVr

MITRACLIP™ TRANSCATHETER MITRAL VALVE REPAIR

MitraClip™ is the first minimally invasive TMVr* therapy that delivers a life-changing treatment option for select patients with primary or secondary mitral regurgitation who would otherwise go untreated.1,2 We continue to innovate with the fourth generation of MitraClip—MitraClip G4—built on the only proven mitral valve therapy with over 17 years of experience, an extensive body of clinical evidence, and more than 100K patients treated worldwide.3

*TMVr is also referred to as TEER (Transcatheter edge-to-edge repair)

Life Changing, Minimally Invasive Procedure

The MitraClip™ TMVr procedure—also referred to as TEER (transcatheter edge-to-edge repair)—is a minimally invasive catheter-based therapy performed by multidisciplinary Heart Teams.1 Open-heart surgery to repair or replace the mitral valve is generally recommended, but it is not an option for many patients.

TMVr with MitraClip therapy delivers a treatment option for select patients with mitral regurgitation (MR) who are not candidates for surgery, or for whom surgery is not the best option.1,2

A better quality of life is possible for your patients with MR


MitraClip™ transcatheter mitral valve repair (TMVr) is a minimally invasive treatment option for select patients with:

  • Significant Primary MR patients who are at a prohibitive surgical risk
  • Significant secondary MR patients who remain symptomatic despite maximally tolerated GDMT

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The Catalyst for a Significant Evolution in MR Guideline

Transcatheter edge-to-edge repair (TEER) therapy is recommended by the 2020 ACC/AHA Guideline4 for select primary and now secondary* MR patients. Determining the severity of MR is an important factor in the management of the condition. The guideline support aggressive monitoring and early action, with the goal of preventing complications due to LV volume overload.4

MitraClip is the only US-approved TEER, serving as the foundation for TEER recommendations for both primary MR and secondary MR.4
 

LEARN ABOUT THE GUIDELINE UPDATES


*Severely symptomatic SMR patients despite optimal GDMT.
 


Severe MR is vastly undertreated

  • Surgical intervention not offered or denied


    49% of patients with symptomatic severe MR were not operated due to age, co-morbidities, or impaired LV.5 If left untreated, MR initiates a cascade of events leading to death, with 1-year mortality up to 57%6

IDENTIFYING PATIENTS FOR MITRACLIP THERAPY


Transcatheter Mitral Valve Repair Patient Screening
Fact Sheet (For Primary MR)

 

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MitraClip Transthoracic Echo (TTE)
Screening Guide

 

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Built to Repair. Proven to Restore.

MitraClip delivers uncompromising performance in TMVr and sets the standard in clinical outcomes. With each generation of MitraClip, Abbott remains at the forefront of therapeutic expertise, partnering with heart teams to help select patients with MR reclaim their lives.

  • Broad Range of Sizes for Tailored Treatment8,9

    MitraClip G4 offers 4 Clip sizes to help tailor repair based on patient mitral valve anatomy.

    • G4 NT is the original MitraClip NT/NTR Clip size
    • G4 XT is the equivalent of XTR, with Clip arms that are 3 mm longer than G4 NT and allow for easier grasping due to better reach**
       

    The G4 NTW and XTW clips have a 50% wider grasping area than the NT and XT clips respectively. They are designed to reduce MR with the implantation of a single clip.**

  • Treat more patients with more options7,8

    Mitraclip successfully treats a broad range of valve anatomies in real world use8,9

    Nearly 1 in 5 patients treated have valve anatomies considered complex8

    Valve anatomies include: presence of severely degenerative leaflets, wide flail gaps or widths, calcified landing zone, wide jet, primary jet outside of A2/P2, and more.8


    Long arm clip use was associated with improved MR reduction for severe baseline MR, smaller annular dimensions, larger prolapse gaps and complex mitral valve anatomy in primary MR.

    – Cardiac Surgeon with over 10 years of experience with MitraClip*
     

    *The testimonial does not provide any indication, guide, warranty or guarantee as to the response patients may have to the treatment or effectiveness of the product or therapy in discussion. Opinions about the treatment discussed can and do vary and are specific to the individual’s experience and might not be representative of others.

    Clip selection recommendations based on mitral valve anatomy1,7,8

    CLIP SELECTION CONSIDERATIONS

    FAVORS
    G4 NTW
    FAVORS
    G4 NT
    FAVORS
    G4 XTW
    FAVORS
    G4 XT
    Leaflet Length < 9mm++  
    Leaflet Length ≥ 9mm  ++
    Broad Jet+ + 
    Smaller Valve +  
    Larger Valve+ ++

    MitraClip G4 Clip selection recommendations are based on the clinical experience of physicians. The EXPAND G4 observational study evaluates adherence to Clip size selection recommendations and their associated outcomes.

  • More options to confirm and optimize leaflet grasping with Controlled Gripper Actuation (CGA)1,3

    Controlled Gripper Actuation (CGA) provides the option to grasp leaflets simultaneously or independently, enabling the ability to confirm and optimize leaflet grasp.

    NEW GRIPPER
    LEVERS

    SIMULTANEOUS
    GRASPING

    INDEPENDENT
    GRASPING

  • Predictable procedure experience7,**

    The innovative Clip Delivery System is a highly maneuverable delivery catheter that is used to implant the MitraClip via a Steerable Guide Catheter.

    Precision and stability from delivery system specifically designed for the mitral valve**
     

  • Increased procedural efficiency1,9

    GREATER PROPORTION
    OF PATIENTS TREATED
    WITH 1 CLIP7

    1 CLIP IMPLANTED IN
    58% OF CASES 7

     

    26% REDUCTION
    IN PROCEDURAL
    TIME7

    34 MIN. AVERAGE
    DEVICE TIME7



    “IN OUR INSTITUTE, WE HAVE NOW REDUCED DEVICE TIME TO ~20 MIN.”

    Echocardiographer with 6 years of MitraClip experience, commenting on MitraClip G4*




     

    Simplified procedural steps1

    • 40% reduction in system preparation steps
    • Simplified system deployment with minimal number of steps
       

LEARN MORE ABOUT MITRACLIP G4 FEATURES BY VISITING MITRACLIP.COM

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Webinars

Watch our webinars to learn more about how MitraClip can benefit physicians and help patients live longer, fuller lives.

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 MAT-2010220 v3.0 | Item approved for U.S. use only.

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