TMVr

MITRACLIP™ TRANSCATHETER MITRAL VALVE REPAIR CLINICAL DATA

MitraClip™ is the first minimally invasive TMVr therapy that delivers a life-changing treatment option for select patients with primary or secondary mitral regurgitation who would otherwise go untreated.1,2 We continue to innovate with the fourth generation of MitraClip—MitraClip G4—built on the only proven mitral valve therapy with over 17 years of experience, an extensive body of clinical evidence, and more than 100K patients treated worldwide.5

A SAFE TREATMENT FOR MITRAL REGURGITATION, A HOPE FOR SELECT PATIENTS

Treating mitral regurgitation (MR) with MitraClip™ therapy can mean an improved quality of life and relief from the symptoms of heart failure. Clinical studies show intervention with MitraClip transcatheter mitral valve repair (TMVr)—also referred to as TEER (transcatheter edge-to-edge repair)—can safely reduce MR in select patients despite their age or high rate of accompanying serious comorbidities, such as heart failure.1

6.3%

30-DAY
MORTALITY RATE

In prohibitive-risk primary MR patients (lower than both mean or median predicted STS mortality risk for either surgical repair or replacement)1

96.6%

FREEDOM FROM
DEVICE-RELATED COMPLICATIONS

Within 12 months in heart failure patients with secondary MR6

EXPAND TREATMENT OPTIONS
FOR SELECT HEART FAILURE PATIENTS

Results from the landmark COAPT™ trial established MitraClip therapy’s impact on heart failure patients with clinically significant secondary MR who remained symptomatic despite maximally tolerated guideline-directed medial therapy. By decreasing MR, patients experienced:

  • Improved survival3
  • Reduction in HF hospitalizations3
  • Improved quality of life4

33%

Relative mortality risk reduction

7.9

# Needed to treat to prevent one death*

* Includes crossover patients (GDMT only patients that were allowed to crossover to MitraClip after 24 months).

REAL-WORLD EXPAND STUDIES SHOW UNPARALLED CLINICAL OUTCOMES2

The EXPAND and EXPAND G4 studies were prospective, multi-center, single arm, international, post-market, real-world, observational studies of patients who received MitraClip NTR/XTR and MitraClip G4, respectively.2
 

ECL Adjudicated MR Severity

 

MR Reduction to ≤ Mild at 30 days achieved in 90.7% of subjects 95.9% had MR reduction to ≤ Moderate.

NOTE: Data not from head to head studies. Data differences depicted between these trials may not be directly comparable, statistically significant, or clinically
meaningful due to differences in trial protocols, endpoints, and/or patient populations. Data provided for informational purposes only.

SEE MORE EXPAND STUDY DATA BY VISITING MITRACLIP.COM

Learn more

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